Gary Wormser reports global immunosuppression from OspA/Borrelia

Gary Wormser says post-Lyme-syndrome is really post-sepsis syndrome, in 2012, with NO INFLAMMATION and NO AUTOIMMUNITY, while ILADS, the other charlatans, and the fake non-profits say nothing.

161123_wormser

http://onlinelibrary.wiley.com/doi/10.1002/art.34386/abstract

Gary Wormser in 2000 saying – while LYMErix was still on the market -, that how sick you become, depends on how much OspA you got stuck with, either by ticks/spirochetes or syringe.  You cant make this up:

“The magnitude of modulation [immunosuppression – KMD] was directly dependent on the quantity of OspA. OspA interferes with the response of lymphocytes to proliferative stimuli including a blocking of cell cycle phase progression.”

“We have previously demonstrated that proteins of B. burgdorferi are capable of modulating human cellular immune responses [7]. Suppression of in vitro mitogen- or antigen-mediated proliferative responses of lymphocytes and reduced production of interleukin-2 (IL-2) from lymphocytes were demonstrated using protein extracts of B. burgdorferi. These early studies were confirmed by a report of de Souza et al. [8], who observed that B. burgdorferi infection in mice resulted in impaired T and B cell proliferation to mitogens and reduced IL-2 and IL-4 production. The nature of the B. burgdorferi proteins responsible for suppression of cellular immunity has not been defined. In this study we examined the modulating activity of a recombinant outer surface protein A (OspA) vaccine preparation on cellular immune responses.”
http://femsim.oxfordjournals.org/content/28/3/193.long


[7].Chiao J.W.Pavia C.P.Riley M.Altman-Lasekin W.Abolhassani M.Liegner K.Mittelman A.

[8]. de Souza M.S.Smith A.L.Beck D.S.Terwilliger G.A.Fikrig E.Barthold S.W.
Wormser’s abstract on how it is OspA that is causing the immunosuppression in 85% of Lyme cases and is the reason this immunosuppression definition was written out of the Dearborn “case definition” and therfore IDSA “guidelines.”  LYMErix was still on the market at the time.  And publicly and in grant applications, Wormser still insists Lyme is only a bad knee, HLA-linked, and is per the falsified Dearborn case definition:
“The modulation of human lymphocyte proliferative responses was demonstrated with a recombinant outer surface protein A (OspA) vaccine preparation for the prevention of Borrelia burgdorferi infection. After exposure to either the unaltered vaccine preparation or OspA prepared in saline, normal lymphocyte responses to the mitogens concanavalin A, phytohemagglutinin-M or pokeweed mitogen, or the antigen BCG were consistently reduced. Whole cell extracts of B. burgdorferi also modulated immune responses but required a much greater quantity of protein than needed for the OspA preparation. The magnitude of modulation was directly dependent on the quantity of OspA. OspA interferes with the response of lymphocytes to proliferative stimuli including a blocking of cell cycle phase progression. Future studies designed to delete the particular region or component of the OspA molecule responsible for this effect may lead to improved vaccine preparations.”http://femsim.oxfordjournals.org/content/28/3/193.long
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